Gary Struhl, Ph.D.Professor, Genetics & Development
Tel +1 212-305-3575
Area of Research
Cell Specification and Differentiation, Neurogenetics
Molecular nature and mode of action of spatial information responsible for organizing cell and body patterns in Drosophila.
Much of our work has been concerned with understanding how the global body pattern is organized by the anterior, posterior, and terminal determinant systems laid down in the egg during oogenesis. More recently, we have begun to examine spatial signaling which controls growth and patterning in cells giving rise to the adult appendages. In both cases, the general approach has been to identify putative signaling molecules, as well as receptors and other cellular components involved in responding to these signals, and then to manipulate these gene products by altering their structures or patterns of expression in vivo. Such experiments indicate in molecular terms what spatial information is, how it arises, and how it governs pattern.
Chen, C.-M., Strapps, W., Tomlinson, A. and Struhl, G (2004). Evidencethat the cysteine -rich domain of Drosophila Frizzled family receptorsis dispensible for transducing Wingless. Proc. Nat. Acad. Sci. U.S.A.,101: 15961-15966.
Wang, W. and Struhl, G. (2004). DSL ligands must undergo Epsin-mediatedendocytosis to activate Notch in Drosophila. Development 131: 5367-80.
Lawrence, P.A., Casal, J. and Struhl, G. (2004). Cell interactions andplanar polarity in the abdominal epidermis of Drosophila. Development131: 4651-4664.
Casali, A. and Struhl, G. (2004). Measuring morphogen concentration asa function of the ratio of bound to unbound receptor. Nature 431: 76-80.
Struhl, G. and Adachi, A. (2000). Requirements for Presenilin-dependentcleavage of Notch and other transmembrane proteins. Molecular Cell 6:625-636.
Lawrence, P.A., and Struhl, G. (1996). Morphogens, Compartments and Pattern: Lessons from Drosophila? Cell 85: 951-961.