Asa Abeliovich, M.D., Ph.D.Associate Professor, Pathology & Cell Biology
Tel +1 212-305-1150
Area of Research
Stem Cell Biology, Neural Degeneration and Repair, Motor Systems
The molecular mechanisms of neurodegeneration and the function and survival of dopamine receptors.
We are studying the molecular bases of midbrain dopamine neuron development, function and survival. Midbrain dopamine neurons are thought to play key roles in learned and addictive behaviors, and degeneration of these neurons underlies Parkinson's disease.
A focus of the lab is to understand the mechanisms by which mutations in Parkinson’s disease-related genes, such as alpha-synuclein and parkin, lead to midbrain dopamine neuron dysfunction and eventual demise. We are also particularly interested in the normal cellular roles of these genes. We use a combination of molecular biological, cellular, and mouse genetic approaches to this end.
In a second project, we are characterizing molecules that play a important roles in the specification and late development of dopamine neurons using an in vitro culture system. Embryonic stem cells have been shown to give rise to dopamine neurons in response to a set of extrinsic cues such as sonic hedgehog and FGF8. Furthermore, a few intrinsic cellular factors, such as nurr1, have been implicated in the generation of dopamine neurons. We are using molecular biological tools to investigate the mechanism by which such intrinsic signals determine midbrain dopamine neuron fate.
Staropoli, J. F., McDermott, C., Martinat, C., Schulman, B., Demireva,E, and Abeliovich, A. (2003). Parkin is a Component of an SCF-likeUbiquitin Ligase Complex and Protects Postmitotic Neurons from KainateExcitotoxicity. Neuron 37: 735-749.
Abeliovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W.-H., Verdugo, J. M. G., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., and Rosenthal, A. (1999). Mice lacking a-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25, 239-252.