Gerard Karsenty, Ph.D.
Tel +1 212-305-6398
Deciphering the molecular pathways used by hypothalamic neurons to regulate bone mass.
Our laboratory has been working on elucidating the genetic pathways underlying each function of the skeleton. One of these functions is to maintain bone mass constant and we have shown that this requires two definite neural outputs: the sympathetic nervous system and cocaine and amphetamine-regulated transcript (CART). Neurons regulating bone mass through these two pathways are located in the ventromedial and arcuate nuclei of the hypothalamus. This body of work led us to explore the role of other neuromediations, mostly serotonin, in the control of bone mass and to launch a molecular effort to identify and clone a receptor for CART.
Fu L, Patel MS, Bradley A, Wagner EF and Karsenty G(2005). The molecular clock mediates leptin-dependent regulation ofbone formation. Cell, 122: 803-15.
Elefteriou F, Ahn JD, Takeda S,Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M,Clement K, Vaisse C and Karsenty G (2005). Leptin regulation of boneresorption via the sympathetic nervous system and CART. Nature, 434:514-20.
ElefteriouF, Takeda S, Ebihara K, Magre J, Patano N, Kim C, Ogawa Y, Liu X,Craigen,W, Robert, J, Vinson C, Nakao K, Capeau J and Karsenty G(2004). Serum leptin level is a regulator of bone mass. Proc Natl AcadSci USA, 101: 3258-3263.
Takeda S, Elefteriou F, Levasseur R, Liu X,Armstrong D, Ducy P and Karsenty G (2002). Leptin regulates boneformation via the sympathetic nervous system. Cell, 111: 305-317.
Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil T, Shen J,Vinson C, Rueger JM and Karsenty G (2000). Leptin inhibits boneformation through a hypothalamic relay: A central control of bone mass.Cell, 100: 197-207.