Ottavio Arancio

Ottavio Arancio, M.D., Ph.D.

Associate Professor, Pathology and Cell Biology

ICRC 1130 St. Nicholas Avenue, 603
Tel +1 212-851-4617

Area of Research

Neural Degeneration and Repair, Neurobiology of Learning and Memory, Biophysics/Ion Channels, Synapses and Circuits


Molecular and cellular mechanisms of synaptic dysfunction leading to memory loss.


Ninan, I., Liu, S., Rabinowitz, D., Arancio, O. (2006). EarlyPresynaptic Changes during Plasticity in Cultured Hippocampal Neurons.EMBO J., 25: 4361-4371.

Gong, B., Cao, Z., Zheng, P., Vitolo, O.V., Liu, S., Staniszewski, A.,Zhang, H., Moolman, D., Shelanski, M., Arancio, O. (2006). UbiquitinHydrolase Uch-L1 Rescues b-Amyloid-Induced Decreases in SynapticFunction and Contextual Memory. Cell, 126: 775-788.

Puzzo, D., Vitolo, O.V., Trinchese, F., Jacob, J.P., Palmeri, A.,Arancio, O. (2005). Amyloid-β-peptide inhibits activation of the nitricoxide/cGMP/CREB pathway during  hippocampal synaptic plasticity. J.Neurosci., 25: 6887-6897.

Gong, B., Vitolo, O.V., Trinchese, F., Liu, S., Shelanski, M., Arancio,O. (2004). Persistent improvement in synaptic and cognitive functionsin an Alzheimer mouse model following rolipram treatment.  J. Clin.Invest ., 114:1624-1634.

Ninan, I., Arancio, O. (2004). Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons.  Neuron, 42:  129-141. Faculty of 1000 Top 10 Neuroscience.