Jay Gingrich, M.D., Ph.D.Sachler Institute Professor of Clinical Developmental Psychology, Psychiatry
Tel +1 212-543-6083
Area of Research
Cognitive/Systems Neuroscience, Models of Psychiatric Disorders, Neurogenetics
Genetic approaches to understanding normal and abnormal brain function in neuropsychiatry.
In our group, we use a systems approach to better understand normal and abnormal brain function. In particular, we study the mechanisms that underlie neuropsychiatric disorders such as schizophrenia, depression, and anxiety disorders. We are interested in understanding how genetic and epigenetic factors affect behavior and intervening systems such as circuitry, anatomy, and physiology. To address these questions, we exploit our ability to genetically modify mice--either to mimic known human susceptibility factors or to use conditional gene modifications (temporal and spatial) to further investigate our hypotheses regarding circuitry and physiology.
Towards these ends, we currently are pursuing several lines of research related to the role of serotonin signaling in the cortex. These studies have demonstrated an important role for cortical influence on behaviors related to schizophrenia and anxiety. We also have an active program examining the role of serotonin on the development of brain circuits that modulate affective and anxiety states. We have also developed a mouse model of epigenetic effects of paternal age on behavior and brain function. These lines of research have opened several avenues of inquiry that we are actively exploring.
Gonzalez-MaesoJ, Weisstaub NV, Zhou M, Chan P, Ivic L, Ang R, Lira A, Bradley-MooreM, Ge Y, Zhou Q, Sealfon SC, Gingrich JA (2007). Hallucinogens recruitspecific cortical 5-HT(2A) receptor-mediated signaling pathways toaffect behavior. Neuron, 53: 439-452.
Ansorge MS, Hen R, Gingrich JA (2007). Neurodevelopmental origins of depressive disorders Curr. Opin. Pharmacol., 7: 8-17.
WeisstaubNV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E,Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, TothM, Aghajanian G, Sealfon SC, Hen R, Gingrich JA (2006). Cortical 5-HT2Areceptor signaling modulates anxiety-like behaviors in mice. Science,313: 536-540.
Gingrich JA (2005). Oxidative stress is the new stress. Nat. Med. 11: 1281-1282.
Ansorge M, Zhou M, Lira A, Hen R, Gingrich JA(2004). Early life blockade of the 5-HT transporter alters emotionalbehavior in adult mice. Science, 306: 879-881.
Gonzalez-MaesoJ, Yuen T, Ebersole BJ, Wurmback E., Lira A., Zhou M., Weisstaub N.,Hen R, Gingrich JA, Sealfon SC (2003). Transcriptome fingerprintsdistinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2Areceptor agonist effects in mouse somatosensory cortex. J. Neurosci.,23: 8836-8843.
Lira A, Zhou M, Castanon N, Ansorge M S, Gordon J A, Francis J H,Bradley-Moore M, Lira J, Underwood M D, Arango V, Hofer MA, Hen R,Gingrich JA. (2003). Altered depression-related behaviors andfunctional changes in the dorsal raphe nucleus of serotonintransporter-deficient mice. Biol. Psych., 54: 960-971.