Jacqueline Gottlieb, Ph.D.Associate Professor, Neuroscience
Tel +1 212-543-6931
Area of Research
Neural mechanisms of attention, learning and decision making
We want to understand how the brain generates intelligent behavior and in particular how it learns, reasons and makes decisions in a changing world. A central interest in the lab is the neural basis of working memory and selective attention. We investigate these functions in the monkey visual system, and combine behavioral and computational techniques with neurophysiological approaches such as reversible inactivation and single- and multi-neuron recording.
A question we are particularly focused on is how the brain endogenously decides how to allocate its resources. How do we decide when and to what to attend? How do we decide which item to commit to memory or process in greater depth? Our working hypothesis is that such acts of focusing have a specific goal, which is to learn, reduce uncertainty or acquire information. We are investigating this process in the parietal and the frontal lobes, two key areas involved in attention control. Future investigations will extend to other areas and neuromodulatory systems.
Gottlieb, J (2012): Attention, learning and the value of information. Neuron 76 (2): 281-295
Gottlieb J, Suzuki M: Distinct neural mechanisms of distractor suppression in the frontal and parietal lobe. Nature Neuroscience, in press
Gottlieb J, Snyder LH. (2010): Spatial and non-spatial information in the parietal lobe. Current Opinion in Neurobiology, 2010 Dec;20(6):731-40
Gottlieb, J and Balan, P. F. (2010): Attention as a decision in information space. Trends in Cognitive Sciences, Vol. 14(6):240-248
Gottlieb, J., Balan P.F., Oristaglio, J, Suzuki M (2008): Parietal control of attentional guidance: The significance of sensory, motivational and motor factors, Neurobiology of Learning and Memory (2009) 91(2):121-128
Peck CJ, Jangraw DC, Suzuki M, Efem R, Gottlieb J. (2009): Reward modulates attention independently of action value in posterior parietal cortex. Journal of Neuroscience, 29(36):11182-91
Gottlieb, J., Balan P.F., (2009): The functional significance of non-spatial information in monkey posterior parietal cortex. Journal of Neuroscience, 29(25):8166-76
Oristaglio J., Schneider D. M., Balan P. F. and Gottlieb J. (2006): Integration of visuospatial and effector information during symbolically cued movements in monkey lateral intraparietal area. Journal of Neuroscience, Aug 9;26(32):8310-9
Balan PF and Gottlieb, J. (2006) Integration of exogenous input into a dynamic salience map revealed by perturbing attention, Journal of Neuroscience, Sept 6; 26(36): 9239-49